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Title 

A pre-structured helix in the intrinsically disordered 4EBP1

Authors 

Do-Hyoung KimChewook LeeYe-Jin ChoSi-Hyung LeeEun Ji ChaJi Eun LimT M SaboC GriesingerD LeeKyou Hoon Han

Publisher 

Royal Society of Chemistry

Issue Date 

2015

Citation 

Molecular Biosystems, vol. 11, no. 2, pp. 366-369

Abstract 

The eIF4E-binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.

ISSN 

1742-206X

Link 

http://dx.doi.org/10.1039/c4mb00532e

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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