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Title 

Nucleoredoxin promotes adipogenic differentiation through regulation of Wnt/beta-catenin signaling

Authors 

Yeong Jae BahnKwang-Pyo LeeSeung Min LeeJeong Yi ChoiY S SeoKi Sun Kwon

Publisher 

American Society for Biochemistry and Molecular Biology

Issue Date 

2015

Citation 

Journal of Lipid Research, vol. 56, no. 2, pp. 294-303

Keywords 

AdipogenesisInflammationObesityWingless/int-1 class(wnt) signaling

Abstract 

Nucleoredoxin (NRX) is a member of the thioredoxin family of proteins that controls redox homeostasis in cell. Redox homeostasis is a well-known regulator of cell differentiation into various tissue types. We found that NRX expression levels were higher in white adipose tissue of obese ob/ob mice and increased in the early adipogenic stage of 3T3-L1 preadipocyte differentiation. Knockdown of NRX decreased differentiation of 3T3-L1 cells, whereas overexpression increased differentiation. Adipose tissuespecifi c NRX transgenic mice showed increases in adipocyte size as well as number compared with WT mice. We further confi rmed that the Wingless/int-1 class (Wnt) /β -catenin pathway was also involved in NRX-promoted adipogenesis, consistent with a previous report showing NRX regulation of this pathway. Genes involved in lipid metabolism were downregulated, whereas inflammatory genes, including those encoding macrophage markers, were signifi cantly upregulated, likely contributing to the obesity in Adipo-NRX mice. Our results therefore suggest that NRX acts as a novel proadipogenic factor and controls obesity in vivo. - Bahn, Y. J., K-P. Lee, S-M. Lee, J. Y. Choi, Y-S. Seo, and K-S. Kwon. Nucleoredoxin promotes adipogenic differentiation through regulation of Wnt/β -catenin signaling. J. Lipid Res. 2015. 56: 294-303.

ISSN 

0022-2275

Link 

http://dx.doi.org/10.1194/jlr.M054056

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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