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Title 

Smart nanoprobes for the detection of alkaline phosphatase activity during osteoblast differentiation

Authors 

Eun Kyung LimJoo Oak KeemH S YunJin Young JeongBong Hyun Chung

Publisher 

Royal Society of Chemistry

Issue Date 

2015

Citation 

Chemical Communications, vol. 51, no. 0, pp. 3270-3272

Abstract 

Gold nanoparticle-conjugated fluorescent hydroxyapatite (AuFHAp) was developed as a smart nanoprobe for measuring alkaline phosphatase (ALP) activity. AuFHAp showed NIR fluorescence due to the hydrolysis of its phosphate groups by ALP. In addition, gold nanoparticles help reduce the nonspecific signal by absorbing nonspecific fluorescence. Through in vitro tests, we confirmed that the AuFHAp probe was capable of detecting ALP levels related to osteoblast activity in living cells with high fluorescence intensity.

ISSN 

1359-7345

Link 

http://dx.doi.org/10.1039/c4cc09620g

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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