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Title 

Identification of plant compounds that disrupt the insect juvenile hormone receptor complex

Authors 

S H LeeHyun Woo OhY FangS B AnDoo-Sang ParkHyuk-Hwan SongSei-Ryang OhS Y KimS KimN KimA S RaikhelY H JeS W Shin

Publisher 

National Academy of Sciences

Issue Date 

2015

Citation 

Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 6, pp. 1733-1738

Keywords 

Endocrine disruptorJuvenile hormoneReceptor

Abstract 

Insects impact human health through vector-borne diseases and cause major economic losses by damaging crops and stored agricultural products. Insect-specific growth regulators represent attractive control agents because of their safety to the environment and humans. We identified plant compounds that serve as juvenile hormone antagonists (PJHANs). Using the yeast twohybrid system transformed with the mosquito JH receptor as a reporter system, we demonstrate that PJHANs affect the JH receptor, methoprene-tolerant (Met), by disrupting its complex with CYCLE or FISC, formation of which is required for mediating JH action. We isolated five diterpene secondary metabolites with JH antagonist activity from two plants: Lindera erythrocarpa and Solidago serotina. They are effective in causing mortality of mosquito larvae at relatively low LD50 values. Topical application of two diterpenes caused reduction in the expression of Met target genes and retardation of follicle development in mosquito ovaries. Hence, the newly discovered PJHANs may lead to development of a new class of safe and effective pesticides.

ISSN 

0027-8424

Link 

http://dx.doi.org/10.1073/pnas.1424386112

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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