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Title 

Saponins, especially platyconic acid A, from Platycodon grandiflorum reduce airway inflammation in ovalbumin-induced mice and PMA-exposed A549 cells

Authors 

J H ChoiS W JinH G KimC Y ChoiHyun Sun LeeS Y RyuY C ChungY J HwangY J UmT C JeongH G Jeong

Publisher 

American Chemical Society

Issue Date 

2015

Citation 

Journal of Agricultural and Food Chemistry, vol. 63, no. 5, pp. 1468-1476

Keywords 

airway inflammationNF-κBPlatycodon grandiflorumplatyconic acid Asaponins

Abstract 

We investigated the inhibitory effects of Platycodon grandiflorum root-derived saponins (Changkil saponins: CKS) on ovalbumin-induced airway inflammation in mice. CKS suppressed leukocytes number, IgE, Th1/Th2 cytokines, and MCP-1 chemokine secretion in bronchoalveolar lavage fluid. Also, ovalbumin-increased MUC5AC, MMP-2/9, and TIMP-1/-2 mRNA expression, NF-κB activation, leukocytes recruitment, and mucus secretion were inhibited by CKS treatment. Moreover, the active component of CKS, platyconic acid A (PA), suppressed PMA-induced MUC5AC mRNA expression (from 2.1 ± 0.2 to 1.1 ± 0.1) by inhibiting NF-κB activation (from 2.3 ± 0.2 to 1.2 ± 0.1) via Akt (from 3.7 ± 0.3 to 2.1 ± 0.2) (p < 0.01) in A549 cells. Therefore, we demonstrate that CKS or PA suppressed the development of respiratory inflammation, hyperresponsiveness, and remodeling by reducing allergic responses, and they may be potential herbal drugs for allergen-induced respiratory disease prevention.

ISSN 

0021-8561

Link 

http://dx.doi.org/10.1021/jf5043954

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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