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Title 

NgR1 expressed in P19 embryonal carcinoma cells differentiated by retinoic acid can activate STAT3

Authors 

S I LeeJi Eun YunJ Y BaekY J JeongJin Ah KimJong Soon KangS H ParkS K KimS K Park

Publisher 

The Korean Physiological Society

Issue Date 

2015

Citation 

Korean Journal of Physiology & Pharmacology, vol. 19, no. 2, pp. 105-109

Keywords 

Neuronal differentiationNMDA receptorNogo receptorP19 cellSTAT3

Abstract 

NgR1, a Nogo receptor, is involved in inhibition of neurite outgrowth and axonal regeneration and regulation of synaptic plasticity. P19 embryonal carcinoma cells were induced to differentiate into neuron-like cells using all trans-retinoic acid and the presence and/or function of cellular molecules, such as NgR1, NMDA receptors and STAT3, were examined. Neuronally differentiated P19 cells expressed the mRNA and protein of NgR1, which could stimulate the phosphorylation of STAT3 when activated by Nogo-P4 peptide, an active segment of Nogo-66. During the whole period of differentiation, mRNAs of all of the NMDA receptor subtypes tested (NR1, NR2A-2D) were consistently expressed, which meant that neuronally differentiated P19 cells maintained some characteristics of neurons, especially central nervous system neurons. Our results suggests that neuronally differentiated P19 cells expressing NgR1 may be an efficient and convenient in vitro model for studying the molecular mechanism of cellular events that involve NgR1 and its binding partners, and for screening compounds that activate or inhibit NgR1.

ISSN 

1226-4512

Link 

http://dx.doi.org/10.4196/kjpp.2015.19.2.105

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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