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Title 

Anti-inflammatory effects of methanol extract of Canarium lyi C.D.Dai & Yakovlev in RAW 264.7 macrophages and a murine model of lipopolysaccharide-induced lung injury

 

카나리움 추출물의 항염효과

Authors 

Ju Mi HongOk-Kyoung KwonIn Sik ShinChan Mi JeonNa Rae ShinJoongku LeeSang-Hong ParkT BachD V HaiSei-Ryang OhS B HanKyung Seop Ahn

Publisher 

Spandidos Publications

Issue Date 

2015

Citation 

International Journal of Molecular Medicine, vol. 35, no. 0, pp. 1403-1410

Keywords 

Acute lung injuryCanarium lyi C.D. Dai & YakovlevInflammationLipopolysaccharide

Abstract 

Canarium lyi C.D. Dai & Yakovlev (CL) is a member of the Anacardiaceae family. To the best of our knowledge, no studies on its anti-inflammatory effects have yet been reported. In the present study, we investigated the protective effects of CL on inflammation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and LPS-induced acute lung injury (ALI) mice. CL attenuated the production of LPS-stimulated inflammatory mediators such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and interleukin-6 (IL-6). Furthermore, CL suppressed phosphorylation of the inhibitor κB-α (IκB-α), p38, c-Jun terminal kinase (JNK) and extracellular signal-regulated kinase (ERK), as well as the translocation of the nuclear factor-κB (NF-κB) p65 subunit into the nucleus. For the in vivo efficacy, the effect of CL on a mouse model of LPS-induced acute lung injury was assessed. CL treatment of the mice significantly inhibited the inflammatory cell recruitment and pro-inflammatory cytokine production in bronchoalveolar lavage fluids (BALF). CL-treated mice also showed a marked inhibition of cyclooxygenase-2 (COX-2) and phosphorylation of IκB and p65. In addition, CL attenuated lung histopathological changes in LPS-induced ALI mice. In conclusion, our results suggest that CL is a potential therapeutic candidate for the treatment of inflammatory diseases, including pneumonia.

ISSN 

1107-3756

Link 

http://dx.doi.org/10.3892/ijmm.2015.2117

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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