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Title 

The GATA factor elt-1 regulates C.elegans developmental timing by promoting expression of the let-7 family microRNAs

Authors 

M L CohenSunhong KimK MoritaSeong Heon KimM Han

Publisher 

Public Library of Science

Issue Date 

2015

Citation 

PLoS Genetics, vol. 11, no. 3, pp. e1005099-e1005099

Abstract 

Postembryonic development in Caenorhabditis elegans is a powerful model for the study of the temporal regulation of development and for the roles of microRNAs in controlling gene expression. Stable switch-like changes in gene expression occur during development as stage-specific microRNAs are expressed and subsequently down-regulate other stage-specific factors, driving developmental progression. Key genes in this regulatory network are phylogenetically conserved and include the post-transcriptional microRNA repressor LIN-28; the nuclear hormone receptor DAF-12; and the microRNAs LIN-4, LET-7, and the three LET-7 family miRNAs (miR-48, miR-84, and miR-241). DAF-12 is known to regulate transcription of miR-48, miR-84 and miR-241, but its contribution is insufficient to account for all of the transcriptional regulation implied by the mutant phenotypes. In this work, the GATA-family transcription factor ELT-1 is identified from a genetic enhancer screen as a regulator of developmental timing in parallel to DAF-12, and is shown to do so by promoting the expression of the LET-7, miR-48, miR-84, and miR-241 microRNAs. The role of ELT-1 in developmental timing is shown to be separate from its role in cell-fate maintenance during post-embryonic development. In addition, analysis of Chromatin Immnoprecipitation (ChIP) data from the modENCODE project and this work suggest that the contribution of ELT-1 to the control of let-7 family microRNA expression is likely through direct transcription regulation.

ISSN 

1553-7390

Link 

http://dx.doi.org/10.1371/journal.pgen.1005099

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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