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Title 

Curcumin mitigates accelerated aging after irradiation in drosophila by reducing oxidative stress

Authors 

K M SeongM YuKyu-Sun LeeS ParkY W JinK J Min

Publisher 

Hindawi Publishing Corporation

Issue Date 

2015

Citation 

BioMed Research International, vol. 2015, no. 0, pp. 425380-425380

Abstract 

Curcumin, belonging to a class of natural phenol compounds, has been extensively studied due to its antioxidative, anticancer, anti-inflammatory, and antineurodegenerative effects. Recently, it has been shown to exert dual activities after irradiation, radioprotection, and radiosensitization. Here, we investigated the protective effect of curcumin against radiation damage using D. melanogaster. Pretreatment with curcumin (100 M) recovered the shortened lifespan caused by irradiation and increased eclosion rate. Flies subjected to high-dose irradiation showed a mutant phenotype of outstretched wings, whereas curcumin pretreatment reduced incidence of the mutant phenotype. Protein carbonylation and formation of γ H2Ax foci both increased following high-dose irradiation most likely due to generation of reactive oxygen species. Curcumin pretreatment reduced the amount of protein carbonylation as well as formation of γ H2Ax foci. Therefore, we suggest that curcumin acts as an oxidative stress reducer as well as an effective protective agent against radiation damage.

ISSN 

2314-6133

Link 

http://dx.doi.org/10.1155/2015/425380

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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