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Title 

Structure and apoptotic function of p73

Authors 

Mi Kyung YoonJi Hyang HaMin Sung LeeSeung-Wook Chi

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2015

Citation 

BMB Reports, vol. 48, no. 2, pp. 81-90

Keywords 

ApoptosisCancer therapyp53 protein familyp73Structure

Abstract 

p73 is a structural and functional homologue of the p53 tumor suppressor protein. Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive genes, conferring its tumor suppressive activity. In addition, p73 has unique roles in neuronal development and differentiation. The importance of p73-induced apoptosis lies in its capability to substitute the pro-apoptotic activity of p53 in various human cancer cells in which p53 is mutated or inactive. Despite the great importance of p73-induced apoptosis in cancer therapy, little is known about the molecular basis of p73-induced apoptosis. In this review, we discuss the p73 structures reported to date, detailed structural comparisons between p73 and p53, and current understanding of the transcription-dependent and -independent mechanisms of p73-induced apoptosis.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2015.48.2.255

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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