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Title 

HExDB: a database for epigenetic changes occurring after horse exercise

Authors 

J A GimS LeeDae Soo KimK S JeongC P HongJ H BaeJ W MoonY S ChoiB W ChoH G ChoJ BhakH S Kim

Publisher 

The Genetics Society of Korea

Issue Date 

2015

Citation 

Genes & Genomics, vol. 37, no. 3, pp. 287-294

Keywords 

Differentially methylated regionExerciseMeDIP-SeqThoroughbred horseTransposable element

Abstract 

DNA methylation is an essential biochemical modification that regulates gene expression. Exercise induces changes in gene expression that adapt as metabolic changes in the blood. We provide a database for the epigenetic changes after horse exercise (http://www.primate.or.kr/hexdb). Horse Exercise Epigenetic Database (HExDB) explicates the change in genome-wide DNA methylation patterns after exercise. Exercise changes the genome-wide epigenetic patterns, and understanding the regions that change is important for confirming exercise physiological mechanisms. For this purpose, our database provides information on differentially methylated regions after exercise that pass a set threshold. A total of 784 genes based on NCBI RefSeq were identified as differentially methylated in equines after exercise. Our database provides clues for the study of exercise-related epigenetic pathways in the thoroughbred horse.

ISSN 

0254-5934

Link 

http://dx.doi.org/10.1007/s13258-014-0251-4

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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