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Title 

Gene expression defines natural changes in mammalian lifespan

Authors 

A A FushanA A TuranovS G LeeE B KimA V LobanovS H YimR BuffensteinSang-Rae LeeKyu Tae ChangH RheeJ S KimK S YangV N Gladyshev

Publisher 

Wiley Open Access

Issue Date 

2015

Citation 

Aging Cell, vol. 14, no. 3, pp. 352-365

Keywords 

AgingGene expressionLife-history traitsLifespanMammals

Abstract 

Mammals differ more than 100-fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney, and brain of 33 diverse species of mammals. Our analysis uncovered parallel evolution of gene expression and lifespan, as well as the associated life-history traits, and identified the processes and pathways involved. These findings provide direct insights into how nature reversibly adjusts lifespan and other traits during adaptive radiation of lineages.

ISSN 

1474-9718

Link 

http://dx.doi.org/10.1111/acel.12283

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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