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Title 

TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse

Authors 

B R NaH R KimI PiragyteHyun-Mee OhM S KwonU AkberH S LeeD S ParkW K SongZ Y ParkS H ImMun Chual RhoY M HyunM KimC D Jun

Publisher 

Rockefeller University Press

Issue Date 

2015

Citation 

Journal of Cell Biology, vol. 209, no. 1, pp. 143-162

Abstract 

The formation of an immunological synapse (IS) requires tight regulation of actin dynamics by many actin polymerizing/depolymerizing proteins. However, the significance of actin stabilization at the IS remains largely unknown. In this paper, we identify a novel function of TAGLN2-an actin-binding protein predominantly expressed in T cells-in stabilizing cortical F-actin, thereby maintaining F-actin contents at the IS and acquiring LFA-1 (leukocyte function-associated antigen-1) activation after T cell receptor stimulation. TAGLN2 blocks actin depolymerization and competes with cofilin both in vitro and in vivo. Knockout of TAGLN2 (TAGLN2-/-) reduced F-actin content and destabilized F-actin ring formation, resulting in decreased cell adhesion and spreading. TAGLN2-/-T cells displayed weakened cytokine production and cytotoxic effector function. These findings reveal a novel function of TAGLN2 in enhancing T cell responses by controlling actin stability at the IS.

ISSN 

0021-9525

Link 

http://dx.doi.org/10.1083/jcb.201407130

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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