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Title 

H3N2 canine influenza virus with the matrix gene from the pandemic A/H1N1 virus: infection dynamics in dogs and ferrets

Authors 

H MoonMin Ki HongJ K KimB SeonWoon Sung NaSeong-Jun ParkD J AnH Y JeoungD J KimJ M KimS H KimR J WebbyR G WebsterB K KangDae Sub Song

Publisher 

Cambridge University Press

Issue Date 

2015

Citation 

Epidemiology and Infection, vol. 143, no. 4, pp. 772-780

Keywords 

transmission

Abstract 

After an outbreak of pandemic influenza A/H1N1 (pH1N1) virus, we had previously reported the emergence of a recombinant canine influenza virus (CIV) between the pH1N1 virus and the classic H3N2 CIV. Our ongoing routine surveillance isolated another reassortant H3N2 CIV carrying the matrix gene of the pH1N1 virus from 2012. The infection dynamics of this H3N2 CIV variant (CIV/H3N2mv) were investigated in dogs and ferrets via experimental infection and transmission. The CIV/H3N2mv-infected dogs and ferrets produced typical symptoms of respiratory disease, virus shedding, seroconversion, and direct-contact transmissions. Although indirect exposure was not presented for ferrets, CIV/H3N2mv presented higher viral replication in MDCK cells and more efficient transmission was observed in ferrets compared to classic CIV H3N2. This study demonstrates the effect of reassortment of the M gene of pH1N1 in CIV H3N2.

ISSN 

0950-2688

Link 

http://dx.doi.org/10.1017/S0950268814001617

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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