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Title 

Effect of Clitocybin A on the proliferation of dermal papilla cells

 

Clitocybin A의 모유두 세포증식 효능

Authors 

J I KangM K KimE S YooIck-Dong YooH K Kang

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2014

Citation 

Korean Journal of Pharmacognosy, vol. 45, no. 4, pp. 288-293

Keywords 

Cell cycleDermal papilla cellsERKHair growthRAFWnt/β-catenin

Abstract 

The present study was conducted to evaluate the hair growth-promoting effect of Clitocybin A from mushroom Clitocybe aurantiaca with dermal papilla cells (DPCs), which play important roles in the regulation of hair cycle. Clitocybin A significantly increased the proliferation of immortalized rat vibrissa DPCs. Flow cytometry analysis revealed that Clitocybin A promoted cell-cycle progression through G0/G1 to S phase in immortalized rat vibrissa DPCs. In addition, Clitocybin A increased the level of cell cycle proteins such as cyclin D1, phospho-pRB, and phospho-CDK2. To elucidate the molecular mechanisms of Clitocybin A on the proliferation of DPCs, we examined the activation of wnt/β-catenin signaling which is known to regulate hair follicle development, differentiation and hair growth. Clitocybin A activated wnt/β-catenin signaling via the increase of phospho(ser552)-β-catenin, phospho(ser675)-β-catenin and phospho(ser9)-GSK3β. Furthermore, Clitocybin A markedly increased the activation of extracellular signal-regulated kinase (ERK). These results suggest that the Clitocybin A may induce hair growth by proliferation of DPCs via cell-cycle progression as well as the activation of Wnt/β-catenin signaling and ERK pathway.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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