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Title 

Discovery of a novel series of indolyl hydrazide derivatives as diacylglycerol acyltransferase-1 inhibitors

Authors 

M KimJ KwonMun-Ock KimS SinghS K KimK LeeHyun Sun LeeY Choi

Publisher 

The Korean Chemical Society

Issue Date 

2015

Citation 

Bulletin of the Korean Chemical Society, vol. 36, no. 2, pp. 628-635

Keywords 

Diacylglycerol O-acyltransferaseDiacylglycerol O-acyltransferase inhibitorHydrazideObesityTriglyceride

Abstract 

A novel series of hydrazide derivatives were synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Among them, compounds 8u and 8v exhibited selective and potent DGAT-1 inhibitory activities. In addition, compound 8u dose-dependently inhibited triglyceride synthesis in HepG2 cell lines. Furthermore, treatment with compound 8u for an oral lipid tolerance test showed a significant decrease in plasma triglyceride levels compared with vehicle-treated control animals, indicating delayed absorption of triglyceride after an acute lipid challenge.

ISSN 

0253-2964

Link 

http://dx.doi.org/10.1002/bkcs.10123

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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