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Title 

Convenient synthesis of novel phenylpyrimido[1,2-c]-thienopyrimidinones as IL-6/STAT3 inhibitors

Authors 

J H ParkS Y HongJ KimH J LeeH H LeeK Y KimSeung Woong LeeHyun-Mee OhMun Chual RhoB G LeeY H Song

Publisher 

Elsevier

Issue Date 

2015

Citation 

Heterocycles, vol. 91, no. 4, pp. 835-848

Abstract 

New phenylpyrimido[1,2-c]thienopyrimidinones 4A and 4B were easily prepared in good yields by the one-pot reaction of formamidine derivatives 2 of 4-aminothienopyrimidine 1 with phenylacetyl chlorides. The application of this convenient and reliable method could be used for the synthesis of a variety of pyrimido[1,2-c]thienopyrimidinone derivatives of biological importance. Some of the compounds synthesized showed strong IL-6/STAT3 inhibition.

ISSN 

0385-5414

Link 

http://dx.doi.org/10.3987/COM-15-13166

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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