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Title 

Low density lipoprotein-oxidation inhibitory phytochemicals from the fruits of rhus parviflora

Authors 

S ShresthaJ H ParkJ G ChoD Y LeeJi Hyun KangH LiTae Sook JeongS K ChoD S LeeN I Baek

Publisher 

Korean Society of Applied Biological Chemistry

Issue Date 

2015

Citation 

Journal of Applied Biological Chemistry, vol. 58, no. 2, pp. 109-112

Keywords 

AnacardiaceaeAnti-hypercholesterolemicAuroneBiflavonoidLow density lipoprotein-oxidationRhus parviflora

Abstract 

Fruits of Rhus parviflora were extracted with 80% aqueous methanol (MeOH), and the concentrated extract was partitioned using ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O, successively. Purification of EtOAc fraction led to isolation of fifteen polyphenols of which structures were identified by spectroscopic methods including 2D-NMR. Most compounds apart from compound 10 inhibited low density lipoproteinoxidation within IC50 value of 10 ?M. Among compounds, taxifolin (2), quercetin 3-O-α-L-rhamnopyranoside (13), agathisflavone (5) sulfuretin (4), and aureusidin (3) showed IC50 values 0.9, 0.8, 5.8, 2.9, and 2.4 ?M which were of highly significant in comparison positive control butylated hydroxytoluene with IC50 value of 2.1 ?M. The results indicate fruits of R. parviflora as a source of antihypercholesterolemic compounds.

ISSN 

1229-2737

Link 

http://dx.doi.org/10.3839/jabc.2015.019

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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