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Title 

Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production

Authors 

Q JinChul LeeJ W LeeD LeeY KimJ T HongJ S KimJ H KimM K LeeB Y Hwang

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2015

Citation 

Chemical & Pharmaceutical Bulletin, vol. 63, no. 5, pp. 384-387

Keywords 

Geranylated flavanoneNitric oxide inhibitorPaulownia coreanaPaulowniaceae

Abstract 

The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 μM.

ISSN 

0009-2363

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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