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Title 

β-Glucan from Aureobasidum species inhibits fat accumulation in 3T3-L1 adipocyte differentiation

Authors 

M J KimO H KimC CheongK H JangChul Ho KimS A Kang

Publisher 

Springer Verlag (Germany)

Issue Date 

2015

Citation 

Food Science and Biotechnology, vol. 24, no. 3, pp. 1147-1150

Keywords 

3T3-L1acetyl CoA carboxylaseadipocyte lipid-binding proteinbacterial derived β-glucanproliferator-activated receptor γ

Abstract 

The anti-fat accumulative effects of bacteria-derived β-glucan in 3T3-L1 adipocyte differentiation was investigated. 3T3-L1 preadipocytes were treated with β-glucan at 50 and 100 μg/mL during adipogenesis. Oil Red O staining was used to study expressions of the adipogenic genes PPARγ, ACC, and aP2. Adipogenesis of 3T3-L1 cells treated with β-glucan at 50 and 100 μg/mL was significantly (p<0.05) inhibited by 32.8 and 39.7%, respectively, compared with controls. Expressions of the PPARγ gene from 3T3-L1 cells treated with β-glucan at 50 and 100 μg/mL were significantly (p<0.05) decreased by 13.6 and 46.1%, respectively, ACC gene expression by 18.3 and 36.0%, respectively, and aP2 gene expression by 36.8 and 56.7%, respectively, compared to adipocyte controls. Bacteria-derived β-glucan inhibits fat accumulation at the cellular level that is mediated via decreases in expressions of the PPARγ, ACC, and aP2 genes.

ISSN 

1226-7708

Link 

http://dx.doi.org/10.1007/s10068-015-0146-4

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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