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Title 

Protein tyrosine phosphatase PTPRT as a regulator of synaptic formation and neuronal development

Authors 

Jae-Ran Lee

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2015

Citation 

BMB Reports, vol. 48, no. 5, pp. 249-255

Keywords 

Dendritic arborizationNeuronal developmentNeuronal synapse formationPTPRTReceptor-type protein tyrosine phosphatase

Abstract 

PTPRT/RPTPρ is the most recently isolated member of the type IIB receptor-type protein tyrosine phosphatase family and its expression is restricted to the nervous system. PTPRT plays a critical role in regulation of synaptic formation and neuronal development. When PTPRT was overexpressed in hippocampal neurons, synaptic formation and dendritic arborization were induced. On the other hand, knockdown of PTPRT decreased neuronal transmission and attenuated neuronal development. PTPRT strengthened neuronal synapses by forming homophilic trans dimers with each other and heterophilic cis complexes with neuronal adhesion molecules. Fyn tyrosine kinase regulated PTPRT activity through phosphorylation of tyrosine 912 within the membrane-proximal catalytic domain of PTPRT. Phosphorylation induced homophilic cis dimerization of PTPRT and resulted in the inhibition of phosphatase activity. BCR-Rac1 GAP and Syntaxin-binding protein were found as new endogenous substrates of PTPRT in rat brain. PTPRT induced polymerization of actin cytoskeleton that determined the morphologies of dendrites and spines by inhibiting BCR-Rac1 GAP activity. Additionally, PTPRT appeared to regulate neurotransmitter release through reinforcement of interactions between Syntaxin-binding protein and Syntaxin, a SNARE protein. In conclusion, PTPRT regulates synaptic function and neuronal development through interactions with neuronal adhesion molecules and the dephosphorylation of synaptic molecules.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2015.48.5.037

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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