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Title 

A new dimeric neolignan from Magnolia grandiflora L. seeds

Authors 

H M LiS R ZhaoQ HuoT MaH LiuJae Kyung LeeYoung-Soo HongC Z Wu

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2015

Citation 

Archives of Pharmacal Research, vol. 38, no. 6, pp. 1066-1071

Keywords 

ApoptosisCytotoxicityMagnolia grandifloraNeolignans

Abstract 

Bioassay-guided fractionation of the MeOH extract of Magnolia grandiflora seeds resulted in the isolation of a new dimeric neolignan, named bishonokiol A (1), as well as two known neolignans magnolol (2) and honokiol (3). The structures of the compounds were determined on the basis of data obtained using NMR and MS. Bishonokiol A (1) showed potent anti-proliferative activities in four human cancer cell lines, with IC50 values ranging from 5.1 to 7.5 μM. Additionally, bishonokiol A (1) induced apoptosis, as well as down-regulated the expression of the anti-apoptotic protein Bcl-2 and caspase-3 cleavage in HepG2 cell line.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-014-0476-4

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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