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Title 

The c-MET network as novel prognostic marker for predicting bladder cancer patients with an increased risk of developing aggressive disease

Authors 

Y W KimS J YunP JeongSeon-Kyu KimSeon-Young KimC YanS P SeoS K LeeJ KimW J Kim

Publisher 

Public Library of Science

Issue Date 

2015

Citation 

Plos One, vol. 10, no. 7, pp. e0134552-e0134552

Abstract 

Previous studies have shown that c-MET is overexpressed in cases of aggressive bladder cancer (BCa). Identification of crosstalk between c-MET and other RTKs such as AXL and PDGFR suggest that c-MET network genes (c-MET-AXL-PDGFR) may be clinically relevant to BCa. Here, we examine whether expression of c-MET network genes can be used to identify BCa patients at increased risk of developing aggressive disease. In vitro analysis, c-MET knockdown suppressed cell proliferation, invasion, and migration, and increased sensitivity to cisplatin-induced apoptosis. In addition, c-MET network gene (c-MET, AXL, and PDGFR) expression allowed discrimination of BCa tissues from normal control tissues and appeared to predict poor disease progression in non-muscle invasive BCa patients and poor overall survival in muscle invasive BCa patients. These results suggest that c-MET network gene expression is a novel prognostic marker for predicting which BCa patients have an increased risk of developing aggressive disease. These genes might be a useful marker for co-targeting therapy, and are expected to play an important role in improving both response to treatment and survival of BCa patients.

ISSN 

1932-6203

Link 

http://dx.doi.org/10.1371/journal.pone.0134552

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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