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Title 

Anti-obesity effects of soy leaf via regulation of adipogenic transcription factors and fat oxidation in diet-induced obese mice and 3T3-L1 adipocytes

Authors 

H LiJ H KangJ M HanM H ChoY J ChungK H ParkD H ShinHo Yong ParkM S ChoiTae Sook Jeong

Publisher 

Mary Ann Liebert

Issue Date 

2015

Citation 

Journal of Medicinal Food, vol. 18, no. 8, pp. 899-908

Keywords 

adipogenesisadipose tissueobesitysoy leaftranscription factor

Abstract 

The anti-obesity effects of extracts from soy leaves (SLE) cultivated for 8 weeks (8W) or 16 weeks (16W) were investigated in diet-induced obese mice. The effects of kaempferol, an aglycone of the kaempferol glycosides that are the major component of 8W-SLE, and coumestrol, the major component of 16W-SLE, were also investigated in 3T3-L1 adipocytes. Eight-week-old male C57BL/6J mice were randomly divided into normal diet, high-fat diet (HFD), 8W-SLE (HFD+8W-SLE 50 mg kg-1 day-1 ), 16W-SLE (HFD+16W-SLE 50 mg kg-1 day-1 ), and Garcinia cambogia extracts (GE) (HFD+GE 50 mg kg-1 day-1 ) groups. Body weight gain and fat accumulation of white adipose tissue (WAT) were highly suppressed by daily oral administration of 8W-SLE and 16W-SLE for 10 weeks. Supplementing a HFD with 8W-SLE and 16W-SLE regulated the mRNA expression of peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/enhancer-binding protein alpha (c/EBPα), sterol regulatory element-binding protein-1 (SREBP-1), adipocyte protein 2, and fatty acid synthase (FAS), which are related to adipogenesis, in addition to hormone-sensitive lipase (HSL), carnitine palmitoyl transferase 1 (CPT-1), and uncoupling protein 2 (UCP2), which are related to fat oxidation in WAT. In 3T3-L1 adipocytes, kaempferol and coumestrol exhibited anti-adipogenic effects via downregulation of PPARγ, c/EBPα, SREBP-1, and FAS. Kaempferol and coumestrol increased the expression of HSL, CPT-1, and UCP2.

ISSN 

1096-620X

Link 

http://dx.doi.org/10.1089/jmf.2014.3388

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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