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Title 

Activation of human natural killer cells by the soluble form of cellular prion protein

Authors 

Y J SeongP S SungY S JangY J ChoiBum Chan ParkS H ParkYoung Woo ParkE C Shin

Publisher 

Elsevier

Issue Date 

2015

Citation 

Biochemical and Biophysical Research Communications, vol. 464, no. 2, pp. 512-518

Keywords 

ActivationCellular prion proteinCytokinesNatural killer cells

Abstract 

Cellular prion protein (PrPC) is widely expressed in various cell types, including cells of the immune system. However, the specific roles of PrPC in the immune system have not been clearly elucidated. In the present study, we investigated the effects of a soluble form of recombinant PrPC protein on human natural killer (NK) cells. Recombinant soluble PrPC protein was generated by fusion of human PrPC with the Fc portion of human IgG1 (PrPC-Fc). PrPC-Fc binds to the surface of human NK cells, particularly to CD56dim NK cells. PrPC-Fc induced the production of cytokines and chemokines and the degranulation of granzyme B from NK cells. In addition, PrPC-Fc facilitated the IL-15-induced proliferation of NK cells. PrPC-Fc induced phosphorylation of ERK-1/2 and JNK in NK cells, and inhibitors of the ERK or the JNK pathways abrogated PrPC-Fc-induced cytokine production in NK cells. In conclusion, the soluble form of recombinant PrPC-Fc protein activates human NK cells via the ERK and JNK signaling pathways.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2015.06.172

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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