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Title 

The incremental induction of neuroprotective properties by multiple therapeutic strategies for primary and secondary neural injury

Authors 

S LeeS ParkJ WonSang-Rae LeeKyu Tae ChangY Hong

Publisher 

MDPI AG

Issue Date 

2015

Citation 

International Journal of Molecular Sciences, vol. 16, no. 8, pp. 19657-19670

Keywords 

ExerciseMelatoninNeural damagesRisk factorsTherapeutic intervention

Abstract 

Neural diseases including injury by endogenous factors, traumatic brain injury, and degenerative neural injury are eventually due to reactive oxygen species (ROS). Thus ROS generation in neural tissues is a hallmark feature of numerous forms of neural diseases. Neural degeneration and the neural damage process is complex, involving a vast array of tissue structure, transcriptional/translational, electrochemical, metabolic, and functional events within the intact neighbors surrounding injured neural tissues. During aging, multiple changes involving physical, chemical, and biochemical processes occur from the molecular to the morphological levels in neural tissues. Among many recommended therapeutic candidates, melatonin also plays a role in protecting the nervous system from anti-inflammation and efficiently safeguards neuronal cells via antioxidants and other endogenous/exogenous beneficial factors. Therefore, given the wide range of mechanisms responsible for neuronal damage, multi-action drugs or therapies for the treatment of neural injury that make use of two or more agents and target several pathways may have greater efficacy in promoting functional recovery than a single therapy alone.

ISSN 

1422-0067

Link 

http://dx.doi.org/10.3390/ijms160819657

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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