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Title 

Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling

Authors 

K LiuChanmi ParkH ChenJoonsung HwangN R ThimmegowdaEun Young BaeKi Won LeeH G KimH LiuNak Kyun SoungC PengJae-Hyuk JangK E KimJong Seog AhnA M BodeZ DongKim Bo Yeon

Publisher 

Wiley-Blackwell

Issue Date 

2015

Citation 

Molecular Carcinogenesis, vol. 54, no. 9, pp. 751-760

Keywords 

AktChemopreventionEupafolinPhosphatidylinositol 3-kinaseProstate cancer

Abstract 

Phosphatase and tensin homolog (PTEN) loss or mutation consistently activates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling pathway, which contributes to the progression and invasiveness of prostate cancer. Furthermore, the PTEN/PI3-K/Akt and Ras/MAPK pathways cooperate to promote the epithelial-mesenchymal transition (EMT) and metastasis initiated from prostate stem/progenitor cells. For these reasons, the PTEN/PI3-K/Akt pathway is considered as an attractive target for both chemoprevention and chemotherapy. Herein we report that eupafolin, a natural compound found in common sage, inhibited proliferation of prostate cancer cells. Protein content analysis indicated that phosphorylation of Akt and its downstream kinases was inhibited by eupafolin treatment. Pull-down assay and in vitro kinase assay results indicated that eupafolin could bind with PI3-K and attenuate its kinase activity. Eupafolin also exhibited tumor suppressive effects in vivo in an athymic nude mouse model. Overall, these results suggested that eupafolin exerts antitumor effects by targeting PI3-K.

ISSN 

0899-1987

Link 

http://dx.doi.org/10.1002/mc.22139

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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