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Title 

Soy leaf extract containing kaempferol glycosides and pheophorbides improves glucose homeostasis by enhancing pancreatic β-cell function and suppressing hepatic lipid accumulation in db/db mice

Authors 

H LiHyeon Seon JiJi Hyun KangD H ShinHo Yong ParkM S ChoiChul Ho LeeI K LeeB S YunTae Sook Jeong

Publisher 

American Chemical Society

Issue Date 

2015

Citation 

Journal of Agricultural and Food Chemistry, vol. 63, no. 32, pp. 7198-7210

Keywords 

glucose homeostasisIRSkaempferolpheophorbide asoy (Glycine max) leafSREBP-1

Abstract 

This study investigated the molecular mechanisms underlying the antidiabetic effect of an ethanol extract of soy leaves (ESL) in db/db mice. Control groups (db/+ and db/db) were fed a normal diet (ND), whereas the db/db-ESL group was fed ND with 1% ESL for 8 weeks. Dietary ESL improved glucose tolerance and lowered plasma glucose, glycated hemoglobin, HOMA-IR, and triglyceride levels. The pancreatic insulin content of the db/db-ESL group was significantly greater than that of the db/db group. ESL supplementation altered pancreatic IRS1, IRS2, Pdx1, Ngn3, Pax4, Ins1, Ins2, and FoxO1 expression. Furthermore, ESL suppressed lipid accumulation and increased glucokinase activity in the liver. ESL primarily contained kaempferol glycosides and pheophorbides. Kaempferol, an aglycone of kaempferol glycosides, improved β-cell proliferation through IRS2-related FoxO1 signaling, whereas pheophorbide a, a product of chlorophyll breakdown, improved insulin secretion and β-cell proliferation through IRS1-related signaling with protein kinase A in MIN6 cells. ESL effectively regulates glucose homeostasis by enhancing IRS-mediated β-cell insulin signaling and suppressing SREBP-1-mediated hepatic lipid accumulation in db/db mice.

ISSN 

0021-8561

Link 

http://dx.doi.org/10.1021/acs.jafc.5b01639

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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