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Title 

Ulleungamides A and B, modified α,β-dehydropipecolic acid containing cyclic depsipeptides from Streptomyces sp. KCB13F003

Authors 

Sangkeun SonSung-Kyun KoMina JangJae Kyoung LeeIn Ja RyooJung-Sook LeeKyung Ho LeeNak Kyun SoungH OhYoung-Soo HongBo Yeon KimJae-Hyuk JangJong Seog Ahn

Publisher 

American Chemical Society

Issue Date 

2015

Citation 

Organic Letters, vol. 17, no. 16, pp. 4046-4049

Abstract 

Two novel cyclic depsipeptides, ulleungamides A (1) and B (2), were isolated from cultures of terrestrial Streptomyces sp. Their structures were determined by analyses of spectroscopic data and various chemical transformations, including modified Mosher's method, advanced Marfey's method, PGME, GITC derivatizations, and Snatzke's method. Ulleungamides were determined to be a new class of peptides bearing unprecedented units, such as 5-hydroxy-6-methyl-2,3-dehydropipecolic acid, 4,5-dihydroxy-6-methyl-2,3-dehydropipecolic acid, and amino-linked 2-isopropylsuccinic acid. Ulleungamide A displayed growth inhibitory activity against Staphylococcus aureus and Salmonella typhimurium without cytotoxicity.

ISSN 

1523-7060

Link 

http://dx.doi.org/10.1021/acs.orglett.5b01969

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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