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Title 

A phenylpropanoid glycoside as a calcineurin inhibitor isolated from Magnolia obovata Thunb.

 

후박으로부터 분리한 칼시뉴린 저해제인 프로파노이드 그라이코사이드

Authors 

Won Jeong LeeJae Sun MoonSung In KimY S BahnH LeeT H KangH M ShinSung Uk Kim

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2015

Citation 

Journal of Microbiology and Biotechnology, vol. 25, no. 9, pp. 1429-1432

Keywords 

Antifungal activityCalcineurin inhibitorCryptococcus neoformansSignaling pathwayTwo-component system

Abstract 

To identify plant-derived cell signaling inhibitors with antifungal properties, a twocomponent screening system using both wild-type Cryptococcus neoformans and a calcineurin mutant was employed owing to their counter-regulatory actions on the Hog1 mitogenactivated protein kinase and calcineurin pathways. Of the 2,000 plant extracts evaluated, a single bioactive compound from M. obovata Thunb. was found to act specifically on the calcineurin pathway of C. neoformans. This compound was identified as magnoloside A, and had potent antifungal activities against various Cryptococcus strains with minimum inhibitory concentration values ranging from 1.0 to 4.0 μg/ml.

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.1506.06031

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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