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Title 

Programming of influenza vaccine broadness and persistence by mucoadhesive polymer-based adjuvant systems

Authors 

H J NohM Y E ChowdhuryS ChoJ H KimH S ParkC J KimHaryoung PooM H SungJ S LeeY T Lim

Publisher 

American Association of Immunologists

Issue Date 

2015

Citation 

Journal of Immunology, vol. 195, no. 5, pp. 2472-2482

Abstract 

The development of an anti-influenza vaccine with the potential for cross-protection against seasonal drift variants as well as occasionally emerging reassortant viruses is essential. In this study, we successfully generated a novel anti-influenza vaccine system combining conserved matrix protein 2 (sM2) and stalk domain of hemagglutinin (HA2) fusion protein (sM2HA2) and poly-γ-glutamic acid (γ-PGA)-based vaccine adjuvant systems that can act as a mucoadhesive delivery vehicle of sM2HA2 as well as a robust strategy for the incorporation of hydrophobic immunostimulatory 3-O-desacyl-4′-monophosphoryl lipid A (MPL) and QS21. Intranasal coadministration of sM2HA2 and the combination adjuvant γ-PGA/MPL/QS21 (CA-PMQ) was able to induce a high degree of protective mucosal, systemic, and cell-mediated immune responses. The sM2HA2/CA-PMQ immunization was able to prevent disease symptoms, confering complete protection against lethal infection with divergent influenza subtypes (H5N1, H1N1, H5N2, H7N3, and H9N2) that lasted for at least 6 mo. Therefore, our data suggest that mucosal administration of sM2HA2 in combination with CA-PMQ could be a potent strategy for a broad cross-protective influenza vaccine, and CA-PMQ as a mucosal adjuvant could be used for effective mucosal vaccines.

ISSN 

0022-1767

Link 

http://dx.doi.org/10.4049/jimmunol.1500492

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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