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Title 

Silica nanoparticles inhibit brown adipocyte differentiation via regulation of p38 phosphorylation

Authors 

Min Jeong SonWon Kon KimM KwakKyoung Jin OhW S ChangJeong Ki MinSang Chul LeeN W SongKwang-Hee Bae

Publisher 

Institute of Physics

Issue Date 

2015

Citation 

Nanotechnology, vol. 26, no. 43, pp. 435101-435101

Keywords 

brown adipogenesisnanotoxicityp38silica nanoparticles

Abstract 

Nanoparticles are of great interest due to their wide variety of biomedical and bioengineering applications. However, they affect cellular differentiation and/or intracellular signaling when applied and exposed to target organisms or cells. The brown adipocyte is a cell type important in energy homeostasis and thus closely related to obesity. In this study, we assessed the effects of silica nanoparticles (SNPs) on brown adipocyte differentiation. The results clearly showed that brown adipocyte differentiation was significantly repressed by exposure to SNPs. The brown adipocyte-specific genes as well as mitochondrial content were also markedly reduced. Additionally, SNPs led to suppressed p38 phosphorylation during brown adipocyte differentiation. These effects depend on the size of SNPs. Taken together, these results lead us to suggest that SNP has anti-brown adipogenic effect in a size-dependent manner via regulation of p38 phosphorylation.

ISSN 

0957-4484

Link 

http://dx.doi.org/10.1088/0957-4484/26/43/435101

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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