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Title 

Intranasal administration of poly-gamma glutamate induced antiviral activity and protective immune responses against H1N1 influenza A virus infection

Authors 

Eun Ha KimY K ChoiC J KimM H SungHaryoung Poo

Publisher 

BioMed Central

Issue Date 

2015

Citation 

Virology Journal, vol. 12, no. 0, pp. 160-160

Keywords 

Antiviral activityCytotoxic T cellsInfluenza virusNK cellPoly-gamma glutamate

Abstract 

Background: The global outbreak of a novel swine-origin strain of the 2009 H1N1 influenza A virus and the sudden, worldwide increase in oseltamivir-resistant H1N1 influenza A viruses highlight the urgent need for novel antiviral therapy. Methods: Here, we investigated the antiviral efficacy of poly-gamma glutamate (γ-PGA), a safe and edible biomaterial that is naturally synthesized by Bacillus subtilis, against A/Puerto Rico/8/1934 (PR8) and A/California/04/2009 (CA04) H1N1 influenza A virus infections in C57BL/6 mice. Results: Intranasal administration of γ-PGA for 5 days post-infection improved survival, increased production of antiviral cytokines including interferon-beta (IFN-β) and interleukin-12 (IL-12), and enhanced activation of natural killer (NK) cells and influenza antigen-specific cytotoxic T lymphocytes (CTL) activity. Conclusions: These results suggest that γ-PGA protects mice against H1N1 influenza A virus by enhancing antiviral immune responses.

ISSN 

1743-422X

Link 

http://dx.doi.org/10.1186/s12985-015-0387-0

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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