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Title 

Neo-clerodane diterpenoids from Scutellaria barbata and their inhibitory effects on LPS-induced nitric oxide production

Authors 

E T YeonJ W LeeC LeeQ JinH JangD LeeJong Seog AhnJ T HongY KimM K LeeB Y Hwang

Publisher 

American Chemical Society

Issue Date 

2015

Citation 

Journal of Natural Products, vol. 78, no. 9, pp. 2292-2296

Abstract 

Three new neo-clerodane diterpenoids (1-3) along with 12 known compounds (4-15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1-3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1-4, 7, and 10-12 were found to inhibit nitric oxide production with IC50 values ranging from 20.2 to 35.6 M.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/acs.jnatprod.5b00126

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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