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Title 

Inhibitory constituents of Sophora tonkinensis on nitric oxide production in RAW 264.7 macrophages

Authors 

J W LeeJ H LeeChul LeeQ JinD LeeY KimJ T HongM K LeeB Y Hwang

Publisher 

Elsevier

Issue Date 

2015

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 25, no. 4, pp. 960-962

Keywords 

LeguminosaeNitric oxide production inhibitorPterocarpanSophora tonkinensis

Abstract 

Bioactivity-guided fractionation of the MeOH extract from the roots of Sophora tonkinensis resulted in the isolation of a new pterocarpan glycoside (1) together with nine known compounds, maackiain (2), sophoranone (3), sophoranochromene (4), pinoresinol (5), syringaresinol (6), medioresinol (7), 4',7-dihydroxyflavone (8), calycosin (9), and genistein (10). The structure of the new compound was determined on the basis of spectroscopic analysis including NMR and CD data in combination with acid hydrolysis. Compounds 1-4 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values ranging from 13.6 to 33.0μM in RAW 264.7 macrophages.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2014.12.012

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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