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Title 

6-O-Veratroyl catalpol suppresses pro-inflammatory cytokines via regulation of extracellular signal-regulated kinase and nuclear factor-κB in human monocytic cells

Authors 

M Q LeM S KimY S SongHyung Won RyuSei-Ryang OhD Y Yoon

Publisher 

Elsevier

Issue Date 

2015

Citation 

Biochimie, vol. 119, no. 0, pp. 52-59

Keywords 

6-O-Veratroyl catalpolAnti-inflammationPMAPro-inflammatory cytokinesTHP-1 cells

Abstract 

The compound 6-O-veratroyl catalpol (6-O) is a bioactive iridoid glucoside that was originally isolated from Pseudolysimachion rotundum var. subintegrum. It has been demonstrated that catapol derivative iridoid glucosides including 6-O, possess anti-inflammatory activity in carragenan-induced paw edema mouse model as well as bronchoalveolar lavage fluid of ovalbumin-induced mouse model. In the present study, we investigated whether 6-O modulates inflammatory responses in THP-1 monocytic cells stimulated with phorbol12-myristate-13-acetate (PMA). Our data showed that 6-O inhibited PMA induced interleukin (IL)-1β and tumor necrosis factor (TNF)-α expression in THP-1 monocytic cells. Mechanistic studies revealed that 6-O suppressed the activity of protein kinase C (PKC), which further resulted in downstream inactivation of extracellular signal-regulated kinase (ERK) and nuclear factor-κB (NF-κB) inflammatory pathway. The results implied that 6-O may protect against inflammatory responses that could be a potential compound in treating inflammatory diseases.

ISSN 

0300-9084

Link 

http://dx.doi.org/10.1016/j.biochi.2015.10.006

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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