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Title 

Inhibitory effects of compounds from Styrax obassia on NO production

Authors 

T Q CaoM H TranJ A KimP T TranJ H LeeM H WooHyeong Kyu LeeB S Min

Publisher 

Elsevier

Issue Date 

2015

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 25, no. 22, pp. 5087-5091

Keywords 

BenzofuranNO productionRAW246.7 cellsStyracaceaeStyrax obassia

Abstract 

Two new benzofurans, 2-(3,4-dimethoxyphenyl)-5-(1,3-dihydroxypropyl)-7-methoxybenzofuran (1) and 2-(3,4-methylenedioxyphenyl)-5-(3-hydroxymethyletoxy-1-hydroxypropyl)-7-methoxybenzofuran (2), a new triterpene, 3β, 6β, 21β-trihydroxyolean-12-ene (3), and eleven known compounds were isolated from the stem bark of Styrax obassia. The structures of the isolated compounds were established by extensive spectroscopic analyses, including 1D and 2D NMR and HRMS. Their anti-inflammatory activities were evaluated against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Compound 1 was shown to reduce LPS-induced iNOS expression in a dose-dependent manner. In addition, pretreating cells with 1 significantly suppressed their LPS-induced expression of COX-2 protein.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2015.10.020

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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