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Title 

Mangosenone F, A furanoxanthone from Garciana mangostana, induces reactive oxygen species-mediated apoptosis in lung cancer cells and decreases xenograft tumor growth

Authors 

K H SeoHyung Won RyuM J ParkK H ParkJ H KimM J LeeH J KangS L KimJ H LeeW D Seo

Publisher 

Wiley-Blackwell

Issue Date 

2015

Citation 

Phytotherapy Research, vol. 29, no. 11, pp. 1753-1760

Keywords 

apoptosiscaspaselung cancer cellmangosenone FROSxenografted nude mice

Abstract 

Mangosenone F (MSF), a natural xanthone, was isolated form Carcinia mangotana, and a few studies have reported its glycosidase inhibitor effect. In this study we investigated the anti lung cancer effect of MSF both in vitro and in vivo. MSF inhibited cancer cell cytotoxicity and induced and induced apoptosis via reactive oxygen species (ROS) generation in NCI-H460. MSF treatment also showed in pronounced release of apoptogenic cytochrome c from the mitochondria to the cytosol, downregulation of Bcl-2 and Bcl-xL, and upregulation of Bax, suggesting that caspase-mediated pathways were involved in MSF-induced apoptosis. ROS activation of the mitogen-activated protein kinase signaling pathway was shown to play a predominant role in the apoptosis mechanism of MSF. Compared with cisplatin treatment, MSF treatment showed significantly increased inhibition of the growth of NCI-H460 cells xenografted in nude mice. Together, these results indicate the potential of MSF as a candidate natural anticancer drug by promoting ROS production.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.5428

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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