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Title 

Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice

Authors 

H J HanJong Hwan ParkBo Yeon KimS N ChangT H KimJ H ParkD J Kim

Publisher 

The Korean Society of Veterinary Science

Issue Date 

2015

Citation 

Journal of Veterinary Science, vol. 16, no. 3, pp. 281-287

Keywords 

Prostate cancerToll-like receptor 4Toll-like receptor 5Transgenic adenocarcinoma of mouse prostate

Abstract 

Chronic inflammation has been considered an important risk factor for development of prostate cancer. Toll-like receptors (TLRs) recognize microbial moieties or endogenous molecules and play an important role in the triggering and promotion of inflammation. In this study, we examined whether expression of TLR4 and TLR5 was associated with progression of prostate transformation in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. The expression of TLR4 and TLR5 was evaluated by immunohistochemisty in formalin-fixed paraffin-embedded prostate tissue from wild-type (WT) and TRAMP mice. Normal prostate tissue from WT mice showed strong expression of TLR4 and TLR5. However, TLR4 expression in the prostate tissue from TRAMP mice gradually decreased as pathologic grade became more aggressive. TLR5 expression in the prostate tissue from TRAMP mice also decreased in low-grade prostate intraepithelial neoplasia (PIN), high-grade PIN and poorly differentiated adenocarcinoma. Overall, our results suggest that decreased expression of TLR4 and TLR5 may contribute to prostate tumorigenesis.

ISSN 

1229-845X

Link 

http://dx.doi.org/10.4142/jvs.2015.16.3.281

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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