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Title 

Brazilein suppresses inflammation through inactivation of IRAK4-NF-κB pathway in LPS-induced Raw264.7 macrophage cells

Authors 

K J KimK Y YoonH S YoonSei-Ryang OhB Y Lee

Publisher 

MDPI AG

Issue Date 

2015

Citation 

International Journal of Molecular Sciences, vol. 16, no. 11, pp. 27589-27598

Keywords 

BrazileinFunctional foodHealth benefitsInflammationIRAK4MAPKNF-κBToll-like receptors

Abstract 

The medicinal herbal plant has been commonly used for prevention and intervention of disease and health promotions worldwide. Brazilein is a bioactive compound extracted from Caesalpinia sappan Linn. Several studies have showed that brazilein exhibited the immune suppressive effect and anti-oxidative function. However, the molecular targets of brazilein for inflammation prevention have remained elusive. Here, we investigated the mechanism underlying the inhibitory effect of brazilein on LPS-induced inflammatory response in Raw264.7 macrophage cells. We demonstrated that brazilein decreased the expression of IRAK4 protein led to the suppression of MAPK signaling and IKKβ, and subsequent inactivation of NF-κB and COX2 thus promoting the expression of the downstream target pro-inflammatory cytokines such as IL-1β, MCP-1, MIP-2, and IL-6 in LPS-induced Raw264.7 macrophage cells. Moreover, we observed that brazilein reduced the production of nitrite compared to the control in LPS-induced Raw264.7. Thus, we suggest that brazilein might be a useful bioactive compound for the prevention of IRAK-NF-κB pathway associated chronic diseases.

ISSN 

1422-0067

Link 

http://dx.doi.org/10.3390/ijms161126048

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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