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Title 

Enzymatic synthesis of novel isobavachalcone glucosides via a UDP-glycosyltransferase

Authors 

H M LiJae Kyung LeeL J NieQ HuoT MaJ K SohngYoung-Soo HongC Z Wu

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2015

Citation 

Archives of Pharmacal Research, vol. 38, no. 12, pp. 2208-2215

Keywords 

CytotoxicityDiversificationGlycosylationIsobavachalconeYjiC

Abstract 

Glycosylation is often used to improve a natural product's properties such as water solubility, chemical stability, pharmacological potency, and structure diversification. In this study, we studied the enzymatic synthesis of novel isobavachalcone glucosides using a UDP-glycosyltransferase (YjiC) from Bacillus licheniformis DSM-13. The chemical structures of compounds 1 and 2 were elucidated by spectroscopic techniques, including LC-MS, MS, and NMR. Meanwhile, the parameters of glycosylation reaction such as incubation time, UDP-glucose concentration, and pH of buffer were also optimized during this study. Furthermore, the compounds 1 and 2 exhibited weak anti-proliferative activities against five human cancer cell lines, with IC50 values ranging from 58.6 to 86.6 μM.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-015-0658-8

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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