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Title 

A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness

Authors 

T KimSuk Jin YangD HwangJ SongM KimS K KimK KangJ AhnD LeeM Y KimS KimJ S KooS S KohSeon-Young KimD S Lim

Publisher 

Nature Publishing Group

Issue Date 

2015

Citation 

Nature Communications, vol. 6, no. 0, pp. 10186-10186

Abstract 

The switch between stem/progenitor cell expansion and differentiation is critical for organ homeostasis. The mammalian Hippo pathway effector and oncoprotein YAP expands undifferentiated stem/progenitor cells in various tissues. However, the YAP-associated transcription factors and downstream targets underlying this stemness-promoting activity are poorly understood. Here we show that the SRF-IL6 axis is the critical mediator of YAP-induced stemness in mammary epithelial cells and breast cancer. Specifically, serum response factor (SRF)-mediated binding and recruitment of YAP to mammary stem cell (MaSC) signature-gene promoters induce numerous MaSC signature genes, among which the target interleukin (IL)-6 is critical for YAP-induced stemness. High SRF-YAP/TAZ expression is correlated with IL6-enriched MaSC/basal-like breast cancer (BLBC). Finally, we show that this high SRF expression enables YAP to more efficiently induce IL6 and stemness in BLBC compared with luminal-type breast cancer. Collectively, our results establish the importance of SRF-YAP-IL6 signalling in promoting MaSC-like properties in a BLBC-specific manner.

ISSN 

2041-1723

Link 

http://dx.doi.org/10.1038/ncomms10186

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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