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Title 

Thymic stromal lymphopoietin induction is mediated by the major whey proteins α-lactalbumin and β-lactoglobulin through the NF-κB pathway in immune cells

Authors 

Jae Min YooY W ParkS Y YoonJ Y SonS G JeongB Y ParkJae Wha KimM S Nam

Publisher 

American Chemical Society

Issue Date 

2015

Citation 

Journal of Agricultural and Food Chemistry, vol. 63, no. 50, pp. 10803-10810

Keywords 

pro-inflammatory cytokineT-helper 2 cytokinethymic stromal lymphopoietinα-lactalbuminβ-lactoglobulin

Abstract 

α-Lactalbumin and β-lactoglobulin are two major whey proteins that specifically bind immunoglobulin E and are suspected as major allergens causing cow's milk allergy (CMA). Recent studies have shown that thymic stromal lymphopoietin is a critical factor linking at the interface of the body and environment to the T-helper 2 response. However, it is not known whether thymic stromal lymphopoietin expression is changed by α-lactalbumin and β-lactoglobulin in immune cells. Using RT-PCR and ELISA, the present study was conducted to examine if intravenous injection of α-lactalbumin and β-lactoglobulin increased pro-inflammatory cytokines, T-helper 2 cytokines, and thymic stromal lymphopoietin expression in several immune cells, including macrophages, mast cells, and keratinocytes. Results showed that α-lactalbumin and β-lactoglobulin induced thymic stromal lymphopoietin, interleukin-6, and tumor necrosis factor-α expression. It was concluded that the allergenicity of α-lactalbumin and β-lactoglobulin may be attributed to thymic stromal lymphopoietin induction, T-helper 2 cytokines, and pro-inflammatory cytokines.

ISSN 

0021-8561

Link 

http://dx.doi.org/10.1021/acs.jafc.5b04790.

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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