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Title 

c-Jun regulates adipocyte differentiation via the KLF15-mediated mode

Authors 

Da Som LeeHyeonjin ChoiBaek Soo HanWon Kon KimSang Chul LeeKyoung Jin OhKwang-Hee Bae

Publisher 

Elsevier

Issue Date 

2016

Citation 

Biochemical and Biophysical Research Communications, vol. 469, no. 3, pp. 552-558

Keywords 

Adipocytec-JUNDifferentiationKLF15Obesity

Abstract 

Abnormal adipocyte differentiation is implicated in the development of metabolic disorders such as obesity and type II diabetes. Thus, an in-depth understanding of the molecular mechanisms associated with adipocyte differentiation is the first step in overcoming obesity and its related metabolic diseases. Here, we examined the role of c-Jun as a transcription factor in adipocyte differentiation. c-Jun overexpression in murine 3T3-L1 preadipocytes significantly inhibited adipocyte differentiation. In addition, the expression level of KLF15, an upstream effector of the key adipogenic factors C/EBPα and PPARγ, was decreased upon the ectopic expression of c-Jun. We found that c-Jun inhibited basal and glucocorticoid receptor (GR)-induced promoter activities of KLF15. c-Jun directly bound near the glucocorticoid response element (GRE) sites in the KLF15 promoter and inhibited adjacent promoter occupancies of GR. Furthermore, the restoration of KLF15 expression in 3T3-L1 cells with the stable ectopic expression of c-Jun partially rescued adipocyte differentiation. Our results demonstrate that c-Jun can suppress adipocyte differentiation through the down-regulation of KLF15 at the transcriptional level. This study proposes a novel mechanism by which c-Jun regulates adipocyte differentiation.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2015.12.035

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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