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Title 

Black phosphorus (BP) nanodots for potential biomedical applications

Authors 

H U LeeS Y ParkS C LeeSaehae ChoiS SeoH KimJ WonK ChoiK S KangH G ParkHee-Sik KimH R AnK H JeongY C LeeJ Lee

Publisher 

Wiley-Blackwell

Issue Date 

2016

Citation 

Small, vol. 12, no. 2, pp. 214-219

Keywords 

black phosphoruscell imagingcytotoxicitymedical applicationsnanodots

Abstract 

Recently, the appeal of 2D black phosphorus (BP) has been rising due to its unique optical and electronic properties with a tunable band gap (?0.3-1.5 eV). While numerous research efforts have recently been devoted to nano- and optoelectronic applications of BP, no attention has been paid to promising medical applications. In this article, the preparation of BP-nanodots of a few nm to <20 nm with an average diameter of ?10 nm and height of ?8.7 nm is reported by a modified ultrasonication-assisted solution method. Stable formation of nontoxic phosphates and phosphonates from BP crystals with exposure in water or air is observed. As for the BP-nanodot crystals' stability (ionization and persistence of fluorescent intensity) in aqueous solution, after 10 d, ?80% at 1.5 mg mL-1 are degraded (i.e., ionized) in phosphate buffered saline. They showed no or little cytotoxic cell-viability effects in vitro involving blue- and green-fluorescence cell imaging. Thus, BP-nanodots can be considered a promising agent for drug delivery or cellular tracking systems.

ISSN 

1613-6810

Link 

http://dx.doi.org/10.1002/smll.201502756

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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