상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV

Authors 

Ji Young ParkJin-A KoD W KimY M KimHyung Jun KwonHyung Jae JeongCha Young KimK H ParkWoo Song LeeYoung Bae Ryu

Publisher 

Informa Healthcare

Issue Date 

2016

Citation 

Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 31, no. 2, pp. 23-30

Keywords 

3CLproAngelica keiskeichalconePLproSARS-CoV

Abstract 

Two viral proteases of severe acute respiratory syndrome coronavirus (SARS-CoV), a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro) are attractive targets for the development of anti-SARS drugs. In this study, nine alkylated chalcones (1-9) and four coumarins (10-13) were isolated from Angelica keiskei, and the inhibitory activities of these constituents against SARS-CoV proteases (3CLpro and PLpro) were determined (cell-free/based). Of the isolated alkylated chalcones, chalcone 6, containing the perhydroxyl group, exhibited the most potent 3CLpro and PLpro inhibitory activity with IC50 values of 11.4 and 1.2 μM. Our detailed protein-inhibitor mechanistic analysis of these species indicated that the chalcones exhibited competitive inhibition characteristics to the SARS-CoV 3CLpro, whereas noncompetitive inhibition was observed with the SARS-CoV PLpro.

ISSN 

1475-6366

Link 

http://dx.doi.org/10.3109/14756366.2014.1003215

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)