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Title 

Streptomyces-derived actinomycin D inhibits biofilm formation by Staphylococcus aureus and its hemolytic activity

Authors 

J H LeeY G KimK LeeChang-Jin KimDong Jin ParkYoonjung JuJ C LeeT K WoodJ Lee

Publisher 

Taylor & Francis

Issue Date 

2016

Citation 

Biofouling, vol. 32, no. 1, pp. 45-56

Keywords 

Actinomycin DbiofilmhemolysishydrophobicityStaphylococcus aureus

Abstract 

Staphylococcus aureus is a versatile human pathogen that produces diverse virulence factors, and its biofilm cells are difficult to eradicate due to their inherent ability to tolerate antibiotics. The anti-biofilm activities of the spent media of 252 diverse endophytic microorganisms were investigated using three S. aureus strains. An attempt was made to identify anti-biofilm compounds in active spent media and to assess their anti-hemolytic activities and hydrophobicities in order to investigate action mechanisms. Unlike other antibiotics, actinomycin D (0.5 μg ml?1) from Streptomyces parvulus significantly inhibited biofilm formation by all three S. aureus strains. Actinomycin D inhibited slime production in S. aureus and it inhibited hemolysis by S. aureus and caused S. aureus cells to become less hydrophobic, thus supporting its anti-biofilm effect. In addition, surface coatings containing actinomycin D prevented S. aureus biofilm formation on glass surfaces. Given these results, FDA-approved actinomycin D warrants further attention as a potential antivirulence agent against S. aureus infections.

ISSN 

0892-7014

Link 

http://dx.doi.org/10.1080/08927014.2015.1125888

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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