상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Genomic and epigenomic heterogeneity in molecular subtypes of gastric cancer

Authors 

Byungho LimJong Hwan KimMirang KimSeon-Young Kim

Publisher 

Baishideng Publishing Group Co. Limited

Issue Date 

2016

Citation 

World Journal of Gastroenterology, vol. 22, no. 3, pp. 1190-1201

Keywords 

DNA methylationGastric cancerMolecular subtypeMutationNext-generation sequencing

Abstract 

Gastric cancer is a complex disease that is affected by multiple genetic and environmental factors. For the precise diagnosis and effective treatment of gastric cancer, the heterogeneity of the disease must be simplified; one way to achieve this is by dividing the disease into subgroups. Toward this effort, recent advances in high-throughput sequencing technology have revealed four molecular subtypes of gastric cancer, which are classified as Epstein-Barr viruspositive, microsatellite instability, genomically stable, and chromosomal instability subtypes. We anticipate that this molecular subtyping will help to extend our knowledge for basic research purposes and will be valuable for clinical use. Here, we review the genomic and epigenomic heterogeneity of the four molecular subtypes of gastric cancer. We also describe a mutational meta-analysis and a reanalysis of DNA methylation that were performed using previously reported gastric cancer datasets.

ISSN 

1007-9327

Link 

http://dx.doi.org/10.3748/wjg.v22.i3.1190

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)