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Title 

Biosynthesis of novel glucosides geldanamycin analogs by enzymatic synthesis

Authors 

Q HuoH M LiJae Kyoung LeeJ LiT MaX ZhangY DaiYoung-Soo HongC Z Wu

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2016

Citation 

Journal of Microbiology and Biotechnology, vol. 26, no. 1, pp. 56-60

Keywords 

CytotoxicityGeldanamycin analogsGlycosyltransferaseWater solubility

Abstract 

Two new glucosides (1 and 2) of geldanamycin (GA) analogs were obtained from in vitro glycosylation by UDP-glycosyltransferase (YjiC). Based on spectroscopic (HR-ESI-MS, 1D, and 2D-NMR) analyses, the glucosides were elucidated as 4,5-dihydro-7-O-descarbamoyl-7- hydroxyl GA-7-O-β-D-glucoside (1) and ACDL3172-18-O-β-D-glucoside (2). Furthermore, the water solubility of compounds 1 and 2 was about 215.2 and 90.7 times higher respectively, than that of the substrates. Among compounds 1-4, only 3 showed weak antiproliferative activity against four human tumor cell lines: MDA-MB-231, SMMC7721, HepG2, and SW480 (IC50: 13.6, 15.1, 31.8, and 22.7 μM, respectively).

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.1508.08069

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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