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Title 

Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015)

Authors 

Hyun Seung BanY UtoMi Sun WonH Nakamura

Publisher 

Taylor & Francis

Issue Date 

2016

Citation 

Expert Opinion on Therapeutic Patents, vol. 26, no. 3, pp. 309-322

Keywords 

cancerCarcinogenesisHIF inhibitorshypoxiahypoxia-inducible factor (HIF)

Abstract 

Introduction: Hypoxia-inducible factor (HIF)-1α regulates the expression of genes involved in angiogenesis, cellular energy metabolism, and cell survival during cancer development. The increased expression of HIF-1α in most solid tumors is associated with poor prognoses and therapeutic outcomes. Therefore, HIF has been recognized as an attractive target for cancer therapy, and many HIF inhibitors have been reported. Areas covered: This patent survey summarizes the information about patented HIF inhibitors over the last 5 years (2011-2015). Expert opinion: Although many of the HIF inhibitors reviewed in this patent survey possess inhibitory activity against cancer and HIF-related diseases, the compounds are still in the early stages of development, most likely due to the complexity of the HIF-1 pathway and their different mechanisms of action for HIF inhibition. Most cancer cells use the glycolytic pathway for energy production and HIF-1α participates deeply in the expression of several glycolytic enzymes. Therefore, a detailed study of HIFs function in cancer metabolisms may provide us an alternative strategy for further development of HIF inhibitors in cancer therapy.

ISSN 

1354-3776

Link 

http://dx.doi.org/10.1517/13543776.2016.1146252

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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